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. Author manuscript; available in PMC: 2021 Sep 16.
Published in final edited form as: Bioconjug Chem. 2020 Sep 2;31(9):2179–2190. doi: 10.1021/acs.bioconjchem.0c00365

Figure 6.

Figure 6.

Inhibitory bioactivity dose response curves of B2036-Alkyne, site-specifically PEGylated B2036, and the multi-PEGylated pegvisomant in Ba/F3-GHR cells. The IC50 values for each GHR antagonist are displayed in the table to the right. All IC50 values were determined to be statistically different from each other (p < 0.05) except for B2036–5k mPEG and B2036–10k mPEG (p > 0.05) using one-way ANOVA with post-hoc analyses (Tukey’s multiple comparisons test). Data is expressed as means with 95% confidence intervals (95% CI) of two individual experiments.