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. 2021 Jul 6;15:648860. doi: 10.3389/fnsys.2021.648860

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Copyright © 2021 Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cerebral metabolic rate of glucose (CMRglc) and FC. (A) The PET scans are compared between awakefulness and uncosciousness induced by general anesthetics (Nielsen et al., 2013). Red areas demonstrate the most significant findings and blue/purple the least, yet significant findings. (B) Group comparison of the FC with two seed regions in the posterior cingulate cortex (PCC) and the thalamus showed widespread reduced corticocortical and thalamocortical connectivity in the anesthetized state (Huang et al., 2014). (C) The metabolic rate of glucose in rat brains decreases correspondingly with the gradually deepened level of propofol anesthesia after intravenous infusion of 20, 40, and 80 mg/kg/h propofol (our unpublished data). (D) Dose-dependent change of brain FC in rat brains (Liu et al., 2013).