Table 2.

Scientific Goals of the All of Us Program and Expected Timelines.^*

Goal	Years
	End of 2018 (N = 94,000)	End of 2019 (N =>200,000)	2020–2022 (N = <650,000)	2023–2027 (N = >1 million)	After 2027 (N = >1 million)
Return data to participants	+	+	+++	+++	++++
Establish demonstration projects†		+	+++	+	+
Discover genetic and environmental correlates with disease			++	+++	++++
Improve predictions of therapeutic safety and efficacy			++	+++	+++
Discover disease biomarkers			++	+++	+++
Connect mobile health, digital health, and sensor data with clinical outcomes			++	+++	+++
Develop new disease classifications			+	+++	++++
Support clinical trials			+	+++	+++
Enable machine-learning applications			++	+++	++++
Improve understanding of health disparities			++	+++	+++
Develop and test new therapeutic agents					++

^*The expected number of participants in the cohort is shown for each time period. The number of plus signs in each cell indicates the anticipated relative degree to which each goal may be accomplished during the estimated timeline for focused research.

^†Demonstration projects are scientific studies implemented by the All of Us program to show the quality, usefulness, validity, and diversity of the All of Us research data set and platform. In these projects, the population and data are further characterized, and the data are evaluated with a view to determining whether known associations can be replicated.