Table 5.
Association between FTO genetic variants and thyroid cancer
| Variant | Codominant model | Dominant model | Recessive model | |||||
|---|---|---|---|---|---|---|---|---|
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| Het vs. hom1 genotypes | Hom2 vs. hom1 genotypes | Het+hom2 vs. hom1 genotypes | Hom2 vs. het+hom1 genotypes | |||||
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| Univariable | Multivariablea) | Univariable | Multivariablea) | Univariable | Multivariablea) | Univariable | Multivariablea) | |
| rs1861868 | 0.68 (0.54–0.85)b) | 0.73 (0.57–0.92)b) | 0.44 (0.23–0.84)b) | 0.48 (0.25–0.95)b) | 0.66 (0.53–0.82)b) | 0.70 (0.56–0.89)b) | 0.50 (0.26–0.95)b) | 0.54 (0.28–1.06) |
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| rs8047395 | 0.95 (0.76–1.20) | 0.90 (0.71–1.16) | 1.39 (1.01–1.92)b) | 1.31 (0.93–1.84) | 1.05 (0.84–1.30) | 0.99 (0.78–1.25) | 1.43 (1.07–1.91)b) | 1.39 (1.02–1.89)b) |
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| rs9937053 | 0.93 (0.74–1.16) | 1.00 (0.79–1.27) | 0.98 (0.49–1.97) | 1.05 (0.51–2.17) | 0.93 (0.75–1.16) | 1.00 (0.80–1.26) | 1.00 (0.50–2.00) | 1.05 (0.51–2.16) |
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| rs9930333 | 0.93 (0.74–1.16) | 1.00 (0.79–1.27) | 0.98 (0.49–1.97) | 1.06 (0.51–2.17) | 0.93 (0.75–1.16) | 1.01 (0.80–1.27) | 1.00 (0.50–2.00) | 1.05 (0.51–2.16) |
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| rs9940128 | 0.93 (0.74–1.16) | 1.00 (0.79–1.27) | 0.98 (0.49–1.97) | 1.06 (0.51–2.17) | 0.93 (0.75–1.16) | 1.01 (0.80–1.27) | 1.00 (0.50–2.00) | 1.05 (0.51–2.16) |
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| rs1421085 | 0.88 (0.68–1.12) | 0.97 (0.75–1.27) | 1.30 (0.55–3.09) | 1.45 (0.59–3.57) | 0.90 (0.71–1.15) | 1.00 (0.77–1.29) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs11642015 | 0.88 (0.69–1.13) | 0.98 (0.75–1.28) | 1.30 (0.55–3.10) | 1.45 (0.59–3.58) | 0.91 (0.71–1.15) | 1.00 (0.78–1.30) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs62048402 | 0.89 (0.69–1.14) | 0.99 (0.76–1.29) | 1.30 (0.55–3.10) | 1.46 (0.59–3.58) | 0.91 (0.72–1.16) | 1.01 (0.78–1.31) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs1558902 | 0.89 (0.69–1.14) | 0.99 (0.76–1.29) | 1.30 (0.55–3.10) | 1.46 (0.59–3.58) | 0.91 (0.72–1.16) | 1.01 (0.78–1.31) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs56094641 | 0.89 (0.70–1.14) | 0.99 (0.76–1.29) | 1.30 (0.55–3.10) | 1.46 (0.59–3.59) | 0.91 (0.72–1.16) | 1.02 (0.79–1.31) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs17817288 | 0.92 (0.73–1.17) | 0.87 (0.68–1.11) | 1.28 (0.94–1.73) | 1.21 (0.87–1.67) | 1.01 (0.80–1.26) | 0.95 (0.75–1.20) | 1.35 (1.03–1.76)b) | 1.32 (1.00–1.75) |
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| rs1477196 | 0.97 (0.78–1.21) | 0.91 (0.72–1.14) | 1.41 (0.97–2.05) | 1.32 (0.89–1.95) | 1.04 (0.85–1.28) | 0.97 (0.78–1.21) | 1.43 (1.00–2.05) | 1.38 (0.94–2.01) |
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| rs55872725 | 0.88 (0.69–1.13) | 0.98 (0.75–1.28) | 1.30 (0.55–3.10) | 1.45 (0.59–3.58) | 0.91 (0.71–1.15) | 1.00 (0.78–1.30) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs1121980 | 0.93 (0.74–1.16) | 1.00 (0.79–1.27) | 0.98 (0.49–1.97) | 1.06 (0.51–2.17) | 0.93 (0.75–1.16) | 1.01 (0.80–1.27) | 1.00 (0.50–2.00) | 1.05 (0.51–2.16) |
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| rs8043757 | 0.92 (0.71–1.18) | 1.00 (0.77–1.31) | 1.32 (0.55–3.13) | 1.46 (0.59–3.59) | 0.94 (0.74–1.20) | 1.03 (0.80–1.34) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs8050136 | 0.91 (0.71–1.16) | 1.00 (0.77–1.30) | 1.31 (0.55–3.11) | 1.46 (0.59–3.60) | 0.93 (0.73–1.18) | 1.03 (0.79–1.33) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs3751812 | 0.91 (0.71–1.17) | 1.01 (0.78–1.32) | 1.31 (0.55–3.11) | 1.46 (0.60–3.61) | 0.93 (0.73–1.19) | 1.04 (0.80–1.34) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs9926289 | 0.91 (0.71–1.17) | 1.01 (0.78–1.32) | 1.31 (0.55–3.11) | 1.46 (0.60–3.61) | 0.93 (0.73–1.19) | 1.04 (0.80–1.34) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs9939609 | 0.91 (0.71–1.17) | 1.01 (0.78–1.32) | 1.31 (0.55–3.11) | 1.46 (0.60–3.61) | 0.93 (0.73–1.19) | 1.04 (0.80–1.34) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs7202116 | 0.91 (0.71–1.17) | 1.01 (0.78–1.32) | 1.31 (0.55–3.11) | 1.46 (0.60–3.61) | 0.93 (0.73–1.19) | 1.04 (0.80–1.34) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs7185735 | 0.91 (0.71–1.17) | 1.01 (0.78–1.32) | 1.31 (0.55–3.11) | 1.46 (0.60–3.61) | 0.93 (0.73–1.19) | 1.04 (0.80–1.34) | 1.33 (0.56–3.16) | 1.46 (0.59–3.59) |
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| rs9930506 | 0.91 (0.73–1.13) | 0.97 (0.77–1.22) | 0.92 (0.46–1.82) | 1.01 (0.50–2.05) | 0.91 (0.73–1.13) | 0.97 (0.77–1.22) | 0.94 (0.48–1.86) | 1.02 (0.50–2.06) |
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| rs8044769 | 0.92 (0.73–1.16) | 0.88 (0.69–1.12) | 1.39 (1.00–1.92) | 1.34 (0.95–1.88) | 1.01 (0.81–1.26) | 0.97 (0.77–1.22) | 1.46 (1.09–1.96)b) | 1.44 (1.05–1.97)b) |
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| rs12149832 | 0.92 (0.72–1.18) | 1.02 (0.79–1.32) | 0.79 (0.31–1.99) | 0.90 (0.34–2.37) | 0.92 (0.72–1.16) | 1.01 (0.79–1.30) | 0.80 (0.32–2.03) | 0.90 (0.34–2.36) |
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| rs11642841 | 0.94 (0.63–1.40) | 1.07 (0.70–1.63) | 2.00 (0.18–22.1) | 4.01 (0.29–55.8) | 0.96 (0.65–1.43) | 1.11 (0.73–1.68) | 2.00 (0.18–22.1) | 4.01 (0.29–55.7) |
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| rs1861867 | 1.06 (0.85–1.32) | 1.01 (0.80–1.27) | 1.29 (0.89–1.88) | 1.23 (0.83–1.83) | 1.10 (0.89–1.35) | 1.04 (0.83–1.30) | 1.25 (0.88–1.79) | 1.23 (0.84–1.78) |
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| rs7195539 | 0.81 (0.61–1.09) | 0.80 (0.59–1.09) | 0.28 (0.06–1.34) | 0.24 (0.05–1.20) | 0.78 (0.59–1.04) | 0.77 (0.57–1.04) | 0.29 (0.06–1.38) | 0.24 (0.05–1.23) |
Values are presented as odds ratios and their 95% confidence intervals from a conditional logistic regression model. FTO, fat mass and obesity-associated; het, heterozygous genotype; hom1, homozygous genotype of major allele; hom2, homozygous genotype of minor allele.
a)
Adjusted for family history of thyroid cancer, marital status, educational level, occupation, monthly income, smoking status, alcohol consumption, and body mass index group,
b)
Significant difference.