Table 6.
Association between FTO haplotypes and thyroid cancer
| Haplotype | Total | Male | Female | |||
|---|---|---|---|---|---|---|
|
|
|
|
||||
| Univariable | Multivariablea) | Univariable | Multivariablea) | Univariable | Multivariablea) | |
| GAAGACA | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
|
| ||||||
| AAAGACA | 0.56 (0.37–0.84)b) | 0.55 (0.36–0.84)b) | 0.94 (0.63–1.38) | 0.88 (0.59–1.30) | 1.07 (0.84–1.36) | 1.06 (0.83–1.36) |
|
| ||||||
| GGAAACA | 1.03 (0.84–1.27) | 1.01 (0.82–1.24) | 0.88 (0.43–1.80) | 0.83 (0.40–1.71) | 0.43 (0.26–0.72)b) | 0.43 (0.25–0.72)b) |
|
| ||||||
| GGAGACA | 1.22 (0.82–1.80) | 1.16 (0.78–1.73) | 1.07 (0.53–2.13) | 0.98 (0.49–1.97) | 1.30 (0.81–2.08) | 1.26 (0.78–2.04) |
Values are presented as odds ratios and their 95% confidence intervals. FTO, fat mass and obesity-associated.
a)
Adjusted for family history of thyroid cancer, marital status, educational level, occupation, monthly income, smoking status, alcohol consumption, and body mass index group,
b)
Significant difference.