Table 9.
Combined effect of body mass index and each polymorphism on thyroid cancer risk in the recessive model
| Variant | Hom1+het normal | Hom1+het overweight | Hom1+het obese | Hom2 normal | Hom2 overweight | Hom2 obese |
|---|---|---|---|---|---|---|
| rs1861868 | 1.00 (reference) | 1.47 (1.09–1.97)a) | 1.58 (1.19–2.10)a) | 0.54 (0.21–1.39) | 1.13 (0.28–4.46) | 0.69 (0.17–2.81) |
| rs8047395 | 1.00 (reference) | 1.55 (1.13–2.12)a) | 1.88 (1.38–2.54)a) | 2.10 (1.28–3.45)a) | 2.38 (1.29–4.40)a) | 1.62 (0.97–2.70) |
| rs9937053 | 1.00 (reference) | 1.54 (1.14–2.06)a) | 1.62 (1.22–2.14)a) | 1.33 (0.36–4.99) | 0.83 (0.23–2.97) | 2.79 (0.78–9.93) |
| rs9930333 | 1.00 (reference) | 1.54 (1.14–2.06)a) | 1.62 (1.22–2.14)a) | 1.33 (0.36–4.99) | 0.83 (0.23–2.97) | 2.79 (0.78–9.93) |
| rs9940128 | 1.00 (reference) | 1.54 (1.14–2.06)a) | 1.62 (1.22–2.14)a) | 1.33 (0.36–4.99) | 0.83 (0.23–2.97) | 2.79 (0.78–9.93) |
| rs1421085 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs11642015 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs62048402 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs1558902 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs56094641 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs17817288 | 1.00 (reference) | 1.64 (1.19–2.25)a) | 1.95 (1.43–2.67)a) | 2.17 (1.37–3.43)a) | 2.11 (1.21–3.67)a) | 1.66 (1.04–2.65)a) |
| rs1477196 | 1.00 (reference) | 1.57 (1.15–2.13)a) | 1.79 (1.34–2.41)a) | 2.51 (1.30–4.84)a) | 2.25 (1.04–4.86)a) | 1.54 (0.85–2.78) |
| rs55872725 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs1121980 | 1.00 (reference) | 1.54 (1.14–2.06)a) | 1.62 (1.22–2.14)a) | 1.33 (0.36–4.99) | 0.83 (0.23–2.97) | 2.79 (0.78–9.93) |
| rs8043757 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs8050136 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs3751812 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs9926289 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs9939609 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs7202116 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs7185735 | 1.00 (reference) | 1.52 (1.14–2.04)a) | 1.61 (1.21–2.13)a) | 1.58 (0.39–6.40) | 1.03 (0.16–6.42) | 4.21 (0.77–22.9) |
| rs9930506 | 1.00 (reference) | 1.53 (1.14–2.05)a) | 1.61 (1.21–2.13)a) | 1.14 (0.33–4.03) | 0.84 (0.24–3.00) | 2.78 (0.78–9.88) |
| rs8044769 | 1.00 (reference) | 1.53 (1.12–2.10)a) | 1.87 (1.38–2.53)a) | 2.06 (1.26–3.38)a) | 2.55 (1.35–4.81)a) | 1.71 (1.02–2.88)a) |
| rs12149832 | 1.00 (reference) | 1.53 (1.14–2.06)a) | 1.61 (1.22–2.14)a) | 1.04 (0.26–4.23) | 0 (0–7.4e+75) | 3.18 (0.57–17.8) |
| rs11642841 | 1.00 (reference) | 1.51 (1.13–2.02)a) | 1.61 (1.22–2.13)a) | 2.10 (0.09–48.8) | ||
| rs1861867 | 1.00 (reference) | 1.54 (1.14–2.09)a) | 1.76 (1.31–2.36)a) | 1.84 (1.00–3.40) | 2.25 (1.02–4.97)a) | 1.37 (0.74–2.54) |
| rs7195539 | 1.00 (reference) | 1.49 (1.12–2.00)a) | 1.63 (1.23–2.16)a) | 0 (0–7.6e+53) | 0.50 (0.04–6.01) | 0.53 (0.05–5.22) |
Values are presented as odds ratios and their 95% confidence intervals from a multivariable conditional logistic regression model, adjusted for family history of thyroid cancer, marital status, educational level, occupation, monthly income, smoking status, alcohol consumption, and body mass index group. het, heterozygous genotype; hom1, homozygous genotype of major allele; hom2, homozygous genotype of minor allele.
a)
Significant difference.