TABLE 2.
Extremes of Thalamic Volume in Subjects Used for Analysis of Neuronal Densities
| Least thalamic volume (n = 12) | Greatest thalamic volume (n = 14) | P | |
|---|---|---|---|
| Age | 54.0 [39.8–60.3] | 56.0 [52.0–64.0] | 0.35 |
| Female sex | 7 | 12 | |
| Race | |||
| White | 7 | 13 | |
| African American | 4 | 1 | |
| Hispanic | 1 | ||
| Disease duration | 19.5 [12.8–25.5] | 16.0 [13.5–28.3] | 0.70 |
| Disease course | RR0 | RR2 | |
| SP 11 | SP 9 | ||
| PP 1 | PP 3 | ||
| Thalamic volume, cm3 | 9.9 [9.2–10.2] | 17.1 [16.6–18.1] | <0.0001 |
| Thalamic lesion volume, cm3 | 0.85 [0.38–1.27] | 0.51 [0.14–0.66] | 0.35 |
| BPF | 0.64 [0.53–0.68] | 0.81 [0.77–0.84] | 0.0001 |
| T2LV, cm3 | 98.1 [74.1–115.7] | 11.0 [3.0–22.0] | <0.0001 |
| T1LV, cm3 | 20.5 [14.4–35.5] | 5.2 [1.6–8.8] | 0.002 |
| WMF | 0.29 [0.26–0.30] | 0.32 [0.31–0.33] | 0.005 |
| GMF | 0.41 [0.35.42] | 0.48 [0.45–0.49] | 0.003 |
BPF = brain parenchymal fraction; GMF = grey matter fraction; T1LV = T1 lesion volume; T2LV = T2 lesion volume; PP = primary progressive; RR = relapsing remitting; SP = secondary progressive; WMF = white matter fraction.