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Tuning transformations for biological application. Bioorthogonal chemistries largely fall into two categories: polar reactions and cycloadditions. Examples of how limitations spurred the development of new reactions are shown.
| Reaction type | Overall transformation | Early example | Tuned variant |
|---|---|---|---|
| Polar |  |
 |
 |
 |
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||
| Cycloaddition |  |
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 |
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