Table 2.

Univariable and multivariable Cox regression of the signature with patient survival in two LGG datasets.

Variables		Univariable				Multivariable
		HR	95% CI of HR		P	HR	95% CI of HR		P
			Lower	Upper			Lower	Upper
TCGA set
Age	>40 vs. ≤ 40	2.82	1.96	4.04	<0.001	1.99	0.52	7.60	0.32
Gender	Male vs. female	1.14	0.81	1.60	0.45	2.00	0.66	6.09	0.22
IDH status	Wild type vs. mutant	5.53	2.07	14.82	<0.001	0.94	0.22	4.07	0.94
LGG Grade	G3 vs. G2	3.31	2.28	4.79	<0.001	0.79	0.22	2.81	0.72
Signature	High risk vs. low risk	6.86	4.26	11.04	<0.001	1.70	1.31	2.21	<0.001
CGGA set
Age	>40 vs. ≤ 40	1.19	0.89	1.58	0.24	1.10	0.82	1.48	0.54
Gender	Male vs. female	1.00	0.75	1.34	0.98	1.14	0.85	1.54	0.38
IDH status	Wild type vs. mutant	2.24	1.64	3.07	<0.001	1.48	1.06	2.07	0.02
Grade	G3 vs. G2	2.62	1.89	3.64	<0.001	2.58	1.81	3.66	<0.001
Signature	High risk vs. low risk	3.68	2.69	5.03	<0.001	3.01	2.12	4.27	<0.001