Table 5.

Bivariate associations of company characteristics with clinical trial transparency measures

Transparency measure	Company size			Company location			Product type
	Large	Non-large	P value	US	Non-US	P value	Biologic	Drug	P value
Public availability of all trials median company score (IQR)	79 (55–93)	39 (27–74)	0.07	39 (32–91)	64 (54–84)	0.25	85 (62–100)	47 (32–82)	0.005
Public availability of patient trials median company score (IQR)	100 (93–100)	100 (67–100)	0.21	100 (80–100)	100 (82–100)	0.64	100 (83–100)	100 (86–100)	0.63
FDAAA compliance median company score (IQR)	100 (88–100)	57 (0–100)	0.01	86 (50–100)	95 (70–100)	0.55	100 (87–100)	100 (50–100)	0.24
Data sharing score median company score (IQR)	100 (80–100)	20 (20–40)	<0.001	50 (20–80)	89 (20–100)	0.28	NA	NA	NA
Overall score median company score (IQR)	96 (91–100)	59 (41–70)	<0.001	73 (54–90)	79 (59–100)	0.24	NA	NA	NA

Data sharing score reflects scores after 30-day amendment period. Mann-Whitney U tests used to determine association between outcome measures and company size, company location and product type. Additional details on company size, company location and products are provided in online supplemental table 4.

FDAAA, Food and Drug Administration Amendments Act; NA, not applicable.