Figure 4: Pediatric TBI increases intrinsic excitability in Layer 2/3 pyramidal neurons in the medial PFC.
A: Membrane voltage; B: Action potential threshold; C: Rheobase; D: Input resistance; E: Neuron firing rate in response to varying levels of current injection. Bar graphs represent mean and error bars represent standard error of the mean from 26 cells for sham + sesame oil (Veh), 34 cells for sham + progesterone (Prog), 37 cells for injured + vehicle and 28 cells for injured + progesterone animals. *, p<0.05 compared to sham-injured animals; #, p<0.05 compared to sham- and brain-injured animals injected with sesame oil.