Table 3.
Burden of Disease in 264 Respiratory Outpatients with Bronchiectasis Followed for 5 Years at Two University Hospitals, Stratified by Treatment with Inhaled Corticosteroids
| Colonization and Exacerbations | No ICS, N = 139a | ICS-Treated, N = 122a | p-valueb |
|---|---|---|---|
| Sputum Culture Performed | 72 (52%) | 87 (71%) | 0.001 |
| Positive Sputum Culture | 29 (21%) | 39 (32%) | 0.041 |
| P. aeruginosa-Positive Sputum Culture | 9 (6.5%) | 24 (20%) | 0.001 |
| History of Any Exacerbations 12 Months Prior to Baseline | 73 (54%, N=134) | 82 (70%, N=117) | 0.011 |
| Of which History Moderate Exacerbations | 73 (54%, N=134) | 81 (70%, N=116) | 0.013 |
| Of Which History of Severe Exacerbations | 29 (21%) | 50 (41%) | <0.001 |
| Annual Exacerbation Rate per Patient during Follow-Up | 0.87 (1.33) | 1.36 (1.76) | 0.012 |
| Of Which Moderate Exacerbations | 0.74 (1.05) | 1.00 (1.32) | 0.089 |
| Of Which Severe Exacerbations | 0.13 (0.50) | 0.36 (0.86) | 0.008 |
| Deceased at End of Follow-Up | 14 (10%) | 25 (20%) | 0.023 |
Notes: aStatistics presented: n (%); mean (SD). No missing data unless specified, N denotes number of patients with data available. b Statistical tests performed: chi-squared, Welch two-sample t-test.
Abbreviation: ICS, inhaled corticosteroid.