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. Author manuscript; available in PMC: 2021 Jul 20.
Published in final edited form as: Nat Struct Mol Biol. 2020 Feb 3;27(2):127–133. doi: 10.1038/s41594-019-0366-z

Fig. 6: RAG2 enforces the target DNA distortion.

Fig. 6:

a, Structure superposition of RAG STC and the hAT family transposase Hermes HFC (PDB: 6DWW) by one RNH domain (left) reveals that the two TIR and flank DNAs complexed with Hermes (colored green) are at a wider angle to each other than 12/23RSS DNAs (orange) and target DNA (purple) with RAG. The curved arrows indicate the narrowed crossing angle of DNA in the RAG STC. b, The RNH catalytic domain and the active site of RAG and Hermes are superimposable. c, With RNH domain superimposed, the flank DNA in Hermes would clash with RAG2 (hot pink).