Figure 5.

The newly proposed model for the crosstalk between mTORC1 and mTORC2 in regulation of cell growth, metabolism, immunity and cancer. In response to nutrients and growth factors, mTORC1 and mTORC2 phosphorylate their respective substrates as indicated to control major cellular functions as indicated. As illustrated, mTORC2 sends positive signals via Akt to mTORC1 by inhibiting its negative regulator TSC complex. Similarly, mTORC2 may also regulate mTORC1 activity by controlling the activity of its upstream nutrient-sensing components such as Gator1.