Table 1. Absolute Values Calculated for Kinetic Parameters in Macroscopic Current Analysis^a.

kinetic parameter	WT (EXP) n = 14	α1 G258V n = 6	β2 L296V n = 7	α1 L300V n = 12	WT (LC) n = 10	β2 G254V n = 10
rise time [ms]	0.41 ± 0.04	0.66 ± 0.04*	0.64 ± 0.06*	0.60 ± 0.07*	1.83 ± 0.19	1.50 ± 0.11
		p < 0.001	p = 0.003	p = 0.037
FR 10	0.30 ± 0.02	0.56 ± 0.04*	0.43 ± 0.04*	0.31 ± 0.02	0.60 ± 0.06	0.45 ± 0.04*
		p< 0.001	p = 0.005			p = 0.047
FR 300	0.15 ± 0.02	0.26 ± 0.03*	0.29 ± 0.03*	0.17 ± 0.01	0.42 ± 0.04	0.28 ± 0.03*
		p = 0.005	p < 0.001			p < 0.001
FR 500	0.13 ± 0.06	0.18 ± 0.03	0.26 ± 0.03*	0.13 ± 0.01	0.36 ± 0.04	0.26 ± 0.02*
			p < 0.001			p = 0.030
τfast [ms]	2.27 ± 0.19	3.71 ± 0.18*	4.90 ± 0.61*	2.42 ± 0.10	4.82 ± 0.26	2.94 ± 0.10*
		p < 0.001	p < 0.001			p = 0.001
τslow [ms]	127.98 ± 9.92	247.19 ± 31.88*	313.09 ± 51.82*	210 ± 26.47*	294.69 ± 51.77	158.48 ± 14.34*
		p < 0.001	p = 0.001	p = 0.021		p = 0.018
%Afast	0.70 ± 0.02	0.42 ± 0.04*	0.61 ± 0.04*	0.69 ± 0.02	0.38 ± 0.10	0.64 ± 0.07*
		p < 0.001	p = 0.042			p = 0.007
%Aslow	0.15 ± 0.03	0.41 ± 0.01*	0.15 ± 0.02	0.19 ± 0.02*	0.26 ± 0.03	0.15 ± 0.02*
		p < 0.001		p = 0.041		p = 0.007
%C	0.14 ± 0.02	0.15 ± 0.04	0.24 ± 0.04*	0.12 ± 0.01	0.36 ± 0.03	0.22 ± 0.02*
			p = 0.013			p < 0.001
deactivation τmean [ms]	383.87 ± 89.49	93.40 ± 21.36*	36.03 ± 5.91*	116.50 ± 10.60*	173.36 ± 37.31	375.42 ± 43.17*
		p < 0.001	p < 0.001	p < 0.001		p = 0.003

^aSignificant changes relative to the respective WT control (EXP = excised-patch or LC = lifted-cell mode) are marked in bold with an asterisk (*), and the corresponding p value is disclosed; n = number of patches.