Table 2. Kinetic and Thermodynamic Parameters of Aβ₄₀ Amyloid Aggregation and Disaggregation.

kinetic parameters	without inhibitor	compound (Cmp.) 18	Cmp. 21
kn (s–1)	3.09 × 10–5	1.45 × 10–6	1.41 × 10–5
ke (M–1 s–1)	486.9	299.5	338.8
t0 (s)	535	1855	995
t1/2 (s)	989	2570	1710
t1 (s)	1444	3284	2424
inhibition%a	0.0	41.0	16.7
disaggregation%b	0.0	34.3	26.8
disaggregation%c	0.0	63.2	56.2

^aKinetic inhibition: [Cmp.] = 10 μM; [Aβ₄₀] = 10 μM (1:1).

^bFiber disaggregation: [Cmp.] = 10 μM; [Aβ₄₀] = 10 μM (1:1).

^cFiber disaggregation: [Cmp.] = 100 μM; [Aβ₄₀] = 10 μM (10:1).