Figure 2.

Dysregulated circadian locomotor activities and hormonal levels in BMAL1-deficient monkeys. (A) Continuous 14-d locomotor activity recorded in BMAL1-WT and BMAL1-KO monkeys. Example actograms of A5, A6, A7 and A3 are shown under L/D conditions. (B and C) Activity amplitude and chi-squared periodograms of the 14-d actograms. (D) Levels of melatonin, testosterone, DHEA and cortisol were assayed for monkey plasma samples obtained from temporal collections at 6-h intervals over 48 h. Results shown are from the male cohort. (E) Female hormonal assays in the same manner as in (D).