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. 2021 Jul 16;14:2741–2752. doi: 10.2147/IDR.S319595

Table 4.

Comparative Analysis of Demographic, Clinical, and Laboratory Data in Acute, Subacute, and Chronic Phases of Brucellosis Patients

Variable Acute (n = 78) Subacute (n = 25) Chronic (n = 6) P value Among Groups (Bonferroni Correction)
Demographics
 Age, y 45.1 ± 17.7 51.6 ± 14.5 47.7 ± 17.0 0.245 n.s
 Male sex 50 (64.1) 18 (72.0) 4 (66.7) 0.874 n.s
Clinical features
 Fever 74 (94.9) 18 (72.0) 5 (83.3) 0.006 acute>subacute
 Chills 42 (53.8) 13 (52.0) 2 (33.3) 0.624 n.s
 Arthralgia 35 (44.9) 13 (52.0) 5 (83.3) 0.188 n.s
 Lose weight 18 (23.1) 13 (52.0) 2 (33.3) 0.023 acute<subacute
 Fatigue 18 (23.1) 11 (44.0) 2 (33.3) 0.109 n.s
 Hyperhidrosis 17 (21.8) 8 (32.0) 3 (50.0) 0.186 n.s
 Anorexia 19 (24.4) 9 (36.0) 0 (0.0) 0.202 n.s
 Myalgia 21 (26.9) 4 (16.0) 2 (33.3) 0.529 n.s
 Cough 18 (23.1) 7 (28.0) 1 (16.7) 0.852 n.s
 Lymphadenectasis 19 (24.4) 7 (28.0) 1 (16.7) 0.925 n.s
 Splenomegaly 15 (19.2) 5 (20.0) 0 (0.0) 0.686 n.s
 Pneumonia 11 (13.9) 5 (20.0) 0 (0.0) 0.623 n.s
Laboratory signs
 Hb 118.5 (107.8–128.25) 123.0 (110.5–128.0) 126.5 (99.0–137.5) 0.623 n.s
 WBC 5.1 (3.4–7.2) 5.9 (3.7–7.5) 6.1 (1.9–10.7) 0.551 n.s
 PLT 186.5 (130.5–254.8) 225.0 (163.0–340.0) 229.0 (138.7–343.0) 0.077 n.s
 ESR 41.5 (25.5–59.8) 40.0 (28.5–74.0) 43.0 (26.8–68.3) 0.697 n.s
 CRP 28.3 (15.5–49.1) 28.2 (7.7–54.2) 34.8 (22.3–65.3) 0.445 n.s
 ALT 39.5 (27.0–67.5) 26.0 (17.5–66.0) 76.0 (29.5–136.3) 0.091 n.s
 AST 38.5 (25.0–65.8) 35.0 (15.5–52.5) 60.5 (38.8–80.8) 0.094 n.s
 LDH 316.0 (218.0–517.5) 209.0 (162.0–276.0) 256.5 (185.8–393.8) <0.001 acute>subacute
 GGT 44.5 (22.8–92.5) 56.0 (24.0–88.0) 114.5 (19.0–223.5) 0.594 n.s
 Creatinine 57.2 (46.4–70.0) 55.0 (49.3–66.0) 58.5 (46.8–70.5) 0.983 n.s
 Urea 4.1 (3.2–4.9) 4.8 (3.5–5.7) 4.2 (2.5–6.8) 0.254 n.s
 APTT 41.2 (36.2–46.2) 43.5 (38.1–48.9) 33.1 (29.5–41.2) 0.049 subacute>chronic
 PT 13.9 (13.1–14.5) 13.9 (13.0–14.7) 12.9 (11.2–14.0) 0.201 n.s
 DD 1.4 (0.9–2.4) 1.2 (0.74–1.6) 0.9 (0.4–2.3) 0.146 n.s
 FDP 4.8 (3.4–9.3) 3.7 (3.0–5.2) 3.7 (2.8–5.4) 0.157 n.s

Note: Data are expressed as number (%) of patients. n.s: adjusted P ≥ 0.05, not significant.