Fig 5.

Mutations in known epitopes of the RBD of SARS-CoV-2 spike protein: A) Frequencies of missense (red) and synonymous (blue) mutations in (from the left to right): residues buried in the Spike protein core, in its exposed residues, in all residues from (structurally characterized) epitopes in RBD, and in all residues involved in binding to the human ACE2 receptor. B) The virus counts of missense mutations in epitopes as a function of the percent of residue’s surface that is involved in the RBD-ACE interface.