Table 1. Comparison of micronucleus frequencies in isogenic trisomic and disomic cells from 69 study participants with mosaicism.
| Finding | Average (Standard Deviation) | Range | P Values |
|---|---|---|---|
| Age at specimen collection | 12.84 (10.52) | 1 to 44 years | |
| Cells with MN | 20.23 (8.59) per 1000 binucleates | 7 to 40 per 1000 binucleates | |
| Percent of trisomic cells in the blood specimens | 33.95% (32.91%) | 4.8% to 96.0% | |
| Relative proportion of cells with MN1 | |||
| Trisomic | 0.37 (0.35) | 0 to 1.51 | <0.0001 |
| Disomic | 0.18 (0.11) | 0 to 0.71 | |
| Relative proportion of cells with atypical abnormal nuclear probe signal patterns2 | |||
| Trisomic | 1.68 (1.21) | 0.02 to 4.69 | <0.0001 |
| Disomic | 0.35 (0.45) | 0.0 to 1.98 |
1Number of MN (micronuclei) in trisomic (or disomic) cells/percentage of trisomic (or disomic) cells
2Number of abnormal, atypical nuclei in trisomic (or disomic) cells/percentage of trisomic (or disomic) cells