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. Author manuscript; available in PMC: 2021 Jul 20.
Published in final edited form as: Biotechnol Bioprocess Eng. 2010 Mar 18;15(1):40–53. doi: 10.1007/s12257-009-3079-z

Table 2.

Lipase-catalyzed kinetic resolution of secondary alcohols by acetylation with vinyl acetate.a

Enzyme Substrate Enantioselectivity
X R THF Toluene EMIM[BF4] BMIM[PF6]
CALB H Bn 140 200 >600 >900
CALB H −CH2C(O)OBn 26 200 >600 150
BCL Cl Ph 56 160 180 >400
BCL Cl OPh 150 85 170 >1000
a

Reaction is in Figure 3c. Enantioselectivity is the ratio of the rate of reaction of the fast-reacting enantiomer over the rate for the slow reacting enantiomer.