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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Mol Cell. 2020 Sep 14;80(1):87–101.e5. doi: 10.1016/j.molcel.2020.08.017

Figure 7. Reducing circulating levels of insulin by SGLT2 inhibitor attenuates the mammary gland tumorigenesis after systemic Akt2 deletion.

Figure 7.

MMTV-ErbB2;Akt2f/f;R26CreERT2 or MMTV-ErbB2;Akt2f/f;R26CreERT2 mice were injected with tamoxifen at 6 weeks of age and were subjected to either control chow diet or diet that includes canagliflozin (CANA). A,C. Insulin level at the indicated time points after chow diet or CANA diet. B,D. Kaplan-Meier curves showing percentage of tumor free mice after chow diet or CANA diet.