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MiR-301a-3p directly targets PTEN.
The sequences of a binding site of miR-301a-3p in the PTEN 3ʹ-UTR at 389–418 nt, and the mutated binding site (A). Luciferase activity assay in Eca-109 cells transfected with NCm, miR-301a-3p mimic, NCi or miR-301a-3p inhibitor (B). The relative protein level of PTEN in Eca-109 cells transfected with adenovirus vectors expressing miR-301a-3p mimic (C) or inhibitor (D). *p < 0.05; **p < 0.01 vs NCm group or NCi group; n = 3.
