Table 2.
Stratified analyses of the pooled HRs of overall survival by tumor type, sample size, survival analysis method, and cutoff value CI: confidence interval; HR: hazard ratio
| Pooled HR (95% CI) |
Heterogeneity |
|||||
|---|---|---|---|---|---|---|
| Subgroup analysis | No. of studies | No. of patients | Fixed model | p-value | I2 (%) | p-value |
| Tumor type | ||||||
| Digestive system tumor | 7 | 406 | 1.67 (1.20, 2.33) | 0.003 | 0.0 | 0.996 |
| Others | 8 | 494 | 2.30 (1.66, 3.19) | <0.001 | 0.0 | 0.836 |
| Sample size | ||||||
| <60 | 8 | 357 | 1.72 (1.21, 2.45) | 0.002 | 0.0 | 0.991 |
| ≥60 | 7 | 543 | 2.18 (1.60, 2.97) | <0.001 | 0.0 | 0.698 |
| Survival analysis method | ||||||
| Univariate | 13 | 696 | 1.89 (1.44, 2.47) | <0.001 | 0.0 | 0.982 |
| Multivariate | 2 | 204 | 2.21 (1.39, 3.52) | 0.001 | 35.4 | 0.213 |
| Cutoff value | ||||||
| Mean | 9 | 493 | 1.69 (1.26, 2.27) | <0.001 | 0.0 | 0.991 |
| Median | 6 | 407 | 2.53 (1.73, 3.69) | <0.001 | 0.0 | 0.889 |