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. 2020 Oct 4;11(1):1058–1070. doi: 10.1080/21655979.2020.1822105

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Omi/HtrA2 specific inhibitor ucf-101 attenuates H₂O₂ -induced apoptosis of PC12 cells. (a) Cell viability was determined by Trypan blue staining. Data are presented as mean ± SD (n = 3). ^#P > 0.05 vs. the control group; ***P < 0.001 vs. the control group; **P < 0.01 vs. the H₂O₂ group. (b) Immunoblotting assays of cleaved caspase 3andBac/Bcl-2 in PC2 cells treated with H₂O₂ (250 μM), ucf-101 (25 μM) and H₂O₂ plus ucf-101 for 6 h. A representative immunoblot is shown. (c) Data are presented as mean ± SD, n = 3. ^#P > 0.05 vs. the control group; ***P < 0.001 vs. the control group or the H₂O₂ group. (d) Hoechst staining of H₂O₂ treated cells. (e) Immunoblotting assays of Omi/HtrA2 and cleaved XIAP in PC2 cells treated with H₂O₂ (250 μM), ucf-101 (25 μM) and H₂O₂ plus ucf-101 for 6 h. A representative immunoblot is shown. (f) Data are presented as mean ± SD, n = 3. ^#P > 0.05 vs. the control group; ***P < 0.001 vs. the control group; **P < 0.01 vs. the H₂O₂ group.