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. 2020 Sep 6;11(1):949–957. doi: 10.1080/21655979.2020.1814670

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Hsa_circ_0000034 served as a sponge of miR-361-3p. (a) The location of hsa_circ_0000034 in retinoblastoma cells were explored by subcellular fractionation assay. (b, c) Venn diagram showed 3 miRNAs bound to hsa_circ_0000034 in circBank and circinteractome databases. (d) The expression of 3 miRNAs (miR-1204, miR-361-3p and miR-769-3p) in si-circRNA transfected retinoblastoma cells. (e) The putative miR-361-3p binding sites in hsa_circ_0000034. (f, g) Dual-luciferase and RIP assays were used to verify the targeting relationship between hsa_circ_0000034 and miR-361-3p. (h) Upregulated hsa_circ_0000034 levels negatively correlated with miR-361-3p expression in retinoblastoma tissues. *p < 0.05.