Table 3.
Subgroup analysis for the association between MPV and the severe GI involvement in HSP
| Subgroup | Study numbers | SMD (95 CI%) | p-value | Heterogeneity |
|
|---|---|---|---|---|---|
| I2 (%) | p-value | ||||
| 1. Age | |||||
| < 7 years | 3 | −0.87 (−2.02–0.29) | 0.14 | 92 | < 0.01 |
| ≥ 7 years | 6 | −0.15 (−0.33–0.04) | 0.11 | 51.0 | 0.07 |
| Combined | 9 | −0.34 (−0.64 – −0.05) | 0.02 | 82.7 | < 0.01 |
| 2. Country | |||||
| China | 4 | −0.03 (−0.23–0.17) | 0.78 | 40.0 | 0.17 |
| Korea | 1 | 0.00 (−0.54–0.54) | 1 | - | - |
| Turkey | 5 | −0.66 (−1.24 – −0.07) | 0.03 | 88.9 | < 0.01 |
| Combined | 10 | −0.29 (−0.56 – −0.01) | 0.04 | 82.1 | < 0.01 |
| 3. Definition of severe GI involvement | |||||
| GI bleeding | 8 | −0.30 (−0.66–0.05) | 0.09 | 83.9 | < 0.01 |
| Other | 2 | −0.26 (−0.80–0.28) | 0.34 | 84.4 | 0.01 |
| Combined | 10 | −0.29 (−0.56 – −0.01) | 0.04 | 82.1 | < 0.01 |
Abbreviation: GI: Gastrointestinal; SMD: standard mean difference; MPV: mean platelet volume; HSP: Henoch-Schonlein Purpura.