Figure 6.

The paracrine factors from infiltrated dendritic cells targeted their receptors in neurons to sensitize pain. (a) The complicated network composed of genes associated with pain using String database to establish (b) and (c). GO process (b) and KEGG pathway (c) analysis indicated that genes were involved in the nerve activation associated with pain. (d–f) The complicated network contained the sub-networks associated with TNF-TNFRSF1A (d), NRG1-EGFR (e), and WNT10A-FZD8 (f) interaction, indicating that these paracrine factor–receptor interactions might participate in the regulation of pain.