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The top transcription factors activated by stimuli of paracrine factors regulated the expression of genes associated with pain. (a–c) ChIP-seq data indicated that the genes associated with pain such as ARRB2 (a), CDK5 (b), and CNR1 (c) could be regulated by some of the top transcription factors. (d) The numbers of genes associated with pain which could be regulated by the top five transcription factors.
