. Author manuscript; available in PMC: 2021 Jul 20.

Published in final edited form as: J Control Release. 2018 Jun 28;286:210–223. doi: 10.1016/j.jconrel.2018.06.030

Table 1.

Comparison of the known effect of chromatin modifying enzyme targets on genomic gene expression and transgene expression as observed in the screen.

Target Modulator	Enzyme Effect on Endogenous Chromatin Expression Activity	Inhibitor Effect on Transient Luciferase (Transgene) Expression
EZH2	Repression[52]	Activation
Gadd45	Activation [53]	Repression
HAT (CBP/p300)	Activation [54]	Repression
HDAC/Sirtuin	Repression [55]	Activation
LSD1	Repression [56]	Activation
HAT (Gcn5/PCAF)	Activation [57]	Activation
WDR5/Menin-MLL^*	Activation^* [58]	Activation

WDR5 and Menin are non-catalytic components of H3K4 methyltransferase complex