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. 2021 Jul 13;10:e65400. doi: 10.7554/eLife.65400

Figure 3. Metabolic effects of volatile anesthetics are uncoupled from sedation and properties common to multiple VA compounds.

Figure 3.

(A) Blood β-HB levels in P7 mice exposed to varying levels of isoflurane as a function of time exposed. 1.5% and baseline as in Figure 1C shown for comparison. Pairwise comparisons versus baseline *p<0.05, ****p<0.0001 by pairwise t-test. p-values color coded to indicate exposure condition. (B) Blood β-HB levels in P7 mice exposed to varying concentrations of isoflurane for 7.5, 15, 30, or 60 min. Median values in baseline and 60 min control treated groups indicated by horizontal lines. (C) Blood glucose levels in P7 mice exposed to varying concentrations of isoflurane for 15 or 30 min. ***p<0.0005, *p<0.05 by pairwise t-test. (D) Blood β-HB levels in P7 mice exposed to sub-anesthetic concentrations of isoflurane, halothane, or sevoflurane for 15 or 30 min. ****p≤0.0001, ***p=0.0003 by pairwise t-test.