Figure 4.

Effects of PAE (30, 100, and 300 mg/kg) treatment on the (a) duration and (b) frequency of entry of mice into the open arms of the elevated plus-maze test versus the effect of diazepam (0.3, 1, and 3 mg/kg) on (c) duration and (d) frequency of entry of mice into the open arms of the elevated plus-maze test. Animals in the control group (Ctrl) received only vehicle. Data are presented as group means ± SEM (n = 7). ^∗∗∗p < 0.001, ^∗∗p < 0.01, and ^∗p < 0.05 (one-way ANOVA followed by Tukey's post hoc comparison test).