Table 2.

Analysis of predictors of PFS.

Variable	Kaplan–Meier analysis			Cox multivariate regression analysis
	HR	95% CI	p	HR	95% CI	p
Age	0.80	0.49–1.29	0.34
Sex	0.66	0.38–1.13	0.16
ECOG PS	0.80	0.41–1.58	0.49
BMI	0.59	0.36–0.96	0.030∗
Smoking	0.91	0.571.48	0.71
Distant metastasis	0.82	0.49–1.36	0.42
Treatment lines	1.05	0.58–1.91	0.86
Bone metastasis	0.38	0.13–1.07	0.0037∗	—	0.25–1.43	0.25
Treatment regimen (anti-PD-1/PD-L1)	2.44	1.06–5.63	0.003∗	2.85	1.47–5.52	0.0051∗
WBC (cutoff = 8.19 × 109/L)	1.89	0.86–4.14	0.038∗	—	0.78–3.84	0.18
ALC (cutoff = 0.635 × 109/L)	2.61	1.39–4.91	0.017∗	—	0.92–13.69	0.06
PLT (cutoff = 201.5 × 109/L)	2.02	1.24–3.26	0.003∗	3.13	1.78–5.52	0.0008∗
LDH (cutoff = 227 U/L)	1.63	0.99–2.67	0.047∗	1.85	1.06–3.24	0.0315∗

^∗Indicators with statistical significance; —Represents no usability data; WBC, white blood cell; LDH, lactate dehydrogenase; PLT, platelet; ALC, absolute lymphocyte count; PD-1, programmed cell death protein-1; PD-L1, programmed cell death ligand-1; BMI: body mass index.