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. 2021 Jul 13;2021:6242798. doi: 10.1155/2021/6242798

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Copyright © 2021 Yongsheng Li et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

WISP1 was targeted by miR-195-5p. (a) TargetScan predicted the binding site between miR-195-5p and WISP1. (b) Dual-luciferase reporter gene assay determined WISP1 was targeted by miR-195-5p. (c) WISP1 was upregulated in CRC tissues. (d) Correlation analysis between AFAP1-AS1 and WISP1 expression in CRC tissues. (e) miR-195-5p expression was negatively correlated with WISP1 expression in CRC tissues. (f) Effects of AFAP1-AS1 and miR-195-5p on WISP1 protein expression. ^∗∗P < 0.01 and ^∗∗∗∗P < 0.0001, compared with the adjacent or miR-NC group.