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. 2021 Jul 6;11:701278. doi: 10.3389/fcimb.2021.701278

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Copyright © 2021 Liu, Han, Blair, Kenst, Qin, Upcin, Wörsdörfer, Midkiff, Mudd, Belyaeva, Milligan, Rorison, Wagner, Bodem, Dölken, Aktas, Vander Heide, Yin, Kolls, Roy, Rappaport, Ergün and Qin

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RNA of SARS-CoV-2 spike protein can be found inside endothelial cells. (A) Representative RNAscope images showed co-localization of RNA of spike protein with CD31 RNA in SARS-CoV-2 infected Ad5-hACE2 mouse lungs (right panel, n = 2), but not in lungs of control mice transduced by DMEM (left panel, n = 3) or Ad5-empty (middle panel, n = 3). White arrow: Spike RNA signals showing light green; black arrow: CD31 RNA signals showing red; yellow arrows: co-localization of two RNAs showing purple. (B) Immunoelectron microscope showed SARS-CoV-2 proteins (black particles indicated by red arrows, n = 1) inside endothelial cells of infected Ad5-hACE2 mice lungs. Pneu, pneumocyte; Er, erythrocyte.