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Overview of the study design. The associations between protein C levels and incident dementia were assessed using two follow-up periods with non-overlapping sets of cases. The midlife baseline was 1987-89 (visit 1) with follow-up period up to the end of 2013. The late-life baseline was 2011-13 (visit 5) with follow-up period up to the end of 2017. Abbreviation. ELISA, enzyme-linked immunosorbent assay.
