Table 3.

Association between circulating protein C levels in late life and incident dementia (n=3,614)

Model	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P-value for trend	Wald test p-value
Model 1	Reference	1.07 (0.80, 1.44)	0.69 (0.50, 0.96)	0.66 (0.46, 0.94)	0.79 (0.55, 1.13)	0.01	0.01
Model 2	Reference	1.21 (0.89, 1.64)	0.78 (0.56, 1.08)	0.71 (0.49, 1.03)	0.92 (0.63, 1.34)	0.07	0.02
Model 3	Reference	1.21 (0.89, 1.63)	0.77 (0.55, 1.07)	0.70 (0.49, 1.02)	0.92 (0.63, 1.35)	0.07	0.02
Model 4	Reference	1.20 (0.89, 1.62)	0.78 (0.56, 1.08)	0.71 (0.49, 1.02)	0.93 (0.64, 1.36)	0.08	0.02
Model 5	Reference	1.26 (0.92, 1.72)	0.78 (0.56, 1.10)	0.73 (0.50, 1.07)	0.84 (0.55, 1.28)	0.04	0.02

Covariates for each model

Model 1: age, sex, race-center, education levels, APOE ε4 carrier status

Model 2: Model 1 + vascular factors (body mass index, current smoking status, prevalent stroke, diabetes and hypertension status, estimated glomerular filtration rate)

Model 3: Model 2 + coagulants (factor VIII, von Willebrand factor) + platelet count

Model 4: Model 3 + incident stoke as time-varying covariate

Model 5: Model 4 incorporating stabilized weights based on the inverse of propensity scores

P-value for trend was obtained by using the five quintiles of protein C as a continuous variable with values from 1 to 5 Wald test p-values were obtained by testing the joint effects of all five quartiles

P-value for proportional hazards assumption for each quintile variable > 0.1 for all