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. Author manuscript; available in PMC: 2022 Aug 6.
Published in final edited form as: J Mol Biol. 2021 Apr 16;433(16):166991. doi: 10.1016/j.jmb.2021.166991

Table 3.

Km values for Nramp homologs, noted here to one significant figure in μM, reported in the indicated references

metal Rat NRAMP2 Human NRAMP2 Human NRAMP1 S.c. Smf1p EcoliNramp DraNramp
Mn2+ 1 [88]
4 [161]		 1 [88] 2 [169] 0.3 [178]
0.3 [145]
0.3 [181]
1 [37]		 2 [136]
2 [132]
3 [132]
Fe2+ 1 [165]
1 [180]
1 [116]
2 [17]
4 [180]		 0.5 [88]
1 [109]
1 [161]
3 [157]
5 [161]		 0.5 [88] 2 [74]
5 [169]		 100 [37] 200 [132]
Co2+ 3 [161] 9 [169] 700 [132]
1000 [132]
Ni2+ 10 [161]
Zn2+ 10 [180] 10 [162]
20 [161]
30 [161]		 0.6 [94] 30 [132]
Cd2+ 0.3 [139]
1 [159]
1 [161]		 3 [142]
9 [142]		 3 [132]
6 [136]
7[132]
Pb2+ 2 [165]
VO2+ 20 [161]

Additionally, Km values for Mn2+ of 20 μM for EcoleNramp [140] and 0.1 μM for S. Typhimurium Nramp [37], and a Km for Fe2+ of 2 μM for mouse NRAMP2 [156], were also reported.