Table 3.

Differentially regulated proteins associated with disorders with dystonia as a sign

Protein	Gene	Disorder	p-value	Difference DRD-WT (Welch’s t-test)	References
Tyrosine hydroxylase	Th	DOPA-responsive dystonia	0.001	−3.72	[16,26]
Translocase of outer mitochondrial membrane 70a	Tomm70a	hypotonia, hyper-reflexia, ataxia, dystonia	0.002	0.75	[38]
Sulfur dioxygenase	Ethe1	ethylmalonic encephalopathy	0.004	0.87	[39]
Flavoprotein subunit of succinate dehydrogenase	Sdha	multisystem mitochondrial disease	0.006	0.15	[40]
Protein kinase C gamma	Prkcg	spinocerebellar ataxia type 14	0.010	−0.31	[41–43]
Succinate-coenzyme A ligase, ADP-forming, beta subunit	Sucla2	dystonia deafness syndrome	0.011	0.25	[44, 45]
Proline-rich transmembrane protein 2	Prrt2	paroxysmal kinesigenic dyskinesias	0.016	−0.56	[46, 47]
GABAA receptor, subunit beta 2	Gabrb2	cervical dystonia	0.019	−0.59	[48]*
Glial fibrillary acidic protein	Gfap	Alexander disease	0.030	0.23	[49, 50]
Arginyl-tRNA synthetase 2, mitochondrial	Rars2	pontocerebellar hypoplasia type 6	0.032	0.74	[51]
OPA1, mitochondrial dynamin like GTPase	Opa1	optic atrophy	0.045	0.21	[52]

^*Indirectly associated