Table 1.

Comparison of area weighted liver shear stiffness values computed using manual and automated methods

Region of interest analysis	Absolute difference (kPa)	Percent difference (%)	Fixed bias p value	Proportional bias, p value	ICC
R1,1-R1,2	0.04 ± 0.13	1.80 ± 2.75	0.231	− 0.06, < 0.001	0.997
R1-R2	0.01 ± 0.22	0.58 ± 5.02	0.657	− 0.03, 0.044	0.992
A95-A90	0.13 ± 0.28	3.24 ± 6.81	< 0.001	0.07, < 0.001	0.988
R1-A95	0.14 ± 0.28	4.80 ± 7.14	< 0.001	− 0.05, 0.017	0.988
R1-A90	0.26 ± 0.28	8.12 ± 6.75	< 0.001	0.03, 0.225	0.986
R2-A95	0.13 ± 0.29	4.20 ± 7.97	< 0.001	− 0.02, 0.461	0.987
R2-A90	0.27 ± 0.33	7.76 ± 7.72	< 0.001	0.06, 0.017	0.982

Unless otherwise indicated, data are reported as the mean ± standard deviation. Manual analysis informed by a 95% confidence mask by Reader 1 (R1), and Reader 2 (R2). Automated analysis using a 95% confidence mask (A95) and 90% confidence mask (A90). Intra-reader comparison for a 95% confidence mask in 20 subjects using Reader 1’s initial set of contours (R1,1) and his repeat contours (R1,2)