Table 2.

Pathways that are differentially regulated between cases with hypertrophic cardiomyopathy and controls with hypertensive left ventricular hypertrophy

Pathway description	Number of matching proteins	Number of proteins in the pathway	False discovery rate
Cytokine-cytokine receptor interaction	28	263	0.0000005
MAPK signaling pathway	26	293	0.00003
PI3K-Akt signaling pathway	28	348	0.00004
Ras signaling pathway	21	228	0.0001
Complement and coagulation cascades	10	78	0.004
Apoptosis	12	135	0.01
Focal adhesion	15	197	0.01
Chemokine signaling pathway	14	181	0.01
TNF signaling pathway	10	108	0.02
Proteasome	6	43	0.03
Rap1 signaling pathway	14	203	0.03
ECM-receptor interaction	8	81	0.03
ErbB signaling pathway	8	83	0.03
TGF-β signaling pathway	8	83	0.03
Fluid shear stress and atherosclerosis	10	133	0.04
JAK-STAT signaling pathway	11	160	0.04

ECM = extracellular matrix; JAK = Janus kinase; MAPK = mitogen-activated protein kinase; PI3K = phosphoinositide 3-kinase; STAT = signal transducer and activator of transcription; TGF = transforming growth factor; TNF = tumor necrosis factor