Table 4.
Pathway analysis of proteins that are correlated with left atrial diameter in patients with hypertrophic cardiomyopathy
| Pathway description | Number of matching proteins | Number of proteins in the pathway | False discovery rate |
|---|---|---|---|
| Complement and coagulation cascades | 20 | 78 | 1.5×10−17 |
| Cytokine-cytokine receptor interaction | 23 | 263 | 2.2×10−10 |
| PI3K-Akt signaling pathway | 19 | 348 | 0.00002 |
| HIF-1 signaling pathway | 9 | 98 | 0.0004 |
| Hematopoietic cell lineage | 8 | 94 | 0.002 |
| Chemokine signaling pathway | 10 | 181 | 0.005 |
| PPAR signaling pathway | 6 | 72 | 0.009 |
| MAPK signaling pathway | 12 | 293 | 0.009 |
| Lysosome | 7 | 123 | 0.02 |
| Focal adhesion | 9 | 197 | 0.02 |
| NF-κB signaling pathway | 6 | 93 | 0.02 |
| Antigen processing and presentation | 5 | 66 | 0.02 |
| Apoptosis | 7 | 135 | 0.02 |
HIF = hypoxia inducible factor; MAPK = mitogen-activated protein kinase; NF-κB = nuclear factor-κB; PI3K = phosphoinositide 3-kinase; PPAR = peroxisome proliferator-activated receptor