Table 5.
Pathway analysis of proteins that are correlated with left ventricular ejection fraction in patients with hypertrophic cardiomyopathy
Pathway description | Number of matching proteins | Number of proteins in the pathway | False discovery rate |
---|---|---|---|
Cytokine-cytokine receptor interaction | 15 | 263 | 0.005 |
Apoptosis | 11 | 135 | 0.005 |
Amino sugar and nucleotide sugar metabolism | 6 | 48 | 0.01 |
NF-κB signaling pathway | 8 | 93 | 0.01 |
MAPK signaling pathway | 14 | 293 | 0.01 |
Metabolic pathways | 35 | 1250 | 0.03 |
JAK-STAT signaling pathway | 9 | 160 | 0.03 |
TNF signaling pathway | 7 | 108 | 0.04 |
JAK = Janus kinase; MAPK = mitogen-activated protein kinase; NF-κB = nuclear factor-κB; STAT = signal transducer and activator of transcription; TNF = tumor necrosis factor