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Aspects of noradrenergic hot spots that may contribute to modulating Aβ and tau release and their impact: 1) Increased vesicle trafficking due to synaptic activity is associated with increased release of Aβ and tau; 2) Increased glutamate release is associated with increased tau release; and 3) β-adrenergic microglial activation modulates toxic effects of Aβ. Figure created with BioRender.com.
