Table 2.
Chemical identity of the annotated metabolites significantly associated with both air pollution and live birth following ART.
| m/z | RT | Validated Metabolite | Adduct Form | Pollutant | (Lag) | % Change per SD Increase in Exp | % Difference by Live Birth (Y vs. N) | Column |
|---|---|---|---|---|---|---|---|---|
| 130.0657 | 30.8 | quinoline | M+H | Dist to A1/A2 Road | −7.7 (−13.5, −1.5) | 15.5 (0.3, 33.1) | HILIC pos | |
| 137.0709 | 44.0 | 1-methylnicotinamide | M+ | NO2 | (1 day) | −7.0 (−12.8, −0.9) | 18.6 (3.5, 36.0) | HILIC pos |
| NO2 | (2 days) | −6.7 (−12.5, −0.5) | ||||||
| NO2 | (3 days) | −6.4 (−12.2, −0.5) | ||||||
| NO2 | (2 weeks) | −6.2 (−12.1, 0.0) | ||||||
| NO2 | (3 months) | −7.6 (−13.3, −1.5) | ||||||
| PM2.5 | (2 weeks) | 7.5 (0.8, 14.6) | ||||||
| Dist to A1/A2 Road | −7.7 (−13.3, −1.5) | |||||||
| 175.1235 | 29.3 | N-methyltryptamine | M+H | Black Carbon | (1 day) | 38.0 (12.4, 69.5) | −37.8 (−59.0, −5.8) | HILIC pos |
| Black Carbon | (2 days) | 39.1 (13.3, 70.8) | ||||||
| Black Carbon | (3 days) | 31.5 (6.9, 61.7) | ||||||
| 183.0657 | 29.5 | methyl vanillate | M+H | O3 | (1 day) | −6.5 (−11.3, −1.6) | 15.6 (3.3, 29.3) | HILIC pos |
| O3 | (2 days) | −6.6 (−11.3, −1.6) | ||||||
| O3 | (3 days) | −6.6 (−11.3, −1.6) | ||||||
| O3 | (1 week) | −6.3 (−11.0, −1.3) | ||||||
| O3 | (2 weeks) | −6.4 (−11.1, −1.4) | ||||||
| O3 | (3 months) | −6.4 (−11.2, −1.4) | ||||||
| PM2.5 | (2 days) | −6.1 (−10.9, −1.1) | ||||||
| PM2.5 | (3 days) | −6.0 (−10.8, −0.9) | ||||||
| Black Carbon | (2 days) | −5.8 (−10.6, −0.7) | ||||||
| Black Carbon | (3 days) | −6.4 (−11.1, −1.4) | ||||||
| 184.0610 | 40.3 | 4-pyridoxate | M+H | Dist to MassDOT Road | 22.7 (0.8, 49.3 | 73.3 (21.9, 146.5) | HILIC pos | |
| 220.1185 | 35.6 | D-pantothenic acid | M+H | Black Carbon | (1 day) | −18.2 (−26.1, −9.4) | 26.1 (1.1, 57.3) | HILIC pos |
| Black Carbon | (2 days) | −13.5 (−21.9, −4.1) | ||||||
| Black Carbon | (3 days) | −11.8 (−20.4, −2.2) | ||||||
| Black Carbon | (2 weeks) | −12.3 (−20.9, −2.8) | ||||||
| Black Carbon | (3 months) | −14.6 (−22.9, −5.5) | ||||||
| 328.2480 | 27.2 | docosahexaenoic acid | M+H | Black Carbon | (1 day) | 10.3 (1.8, 19.4) | 20.8 (1.9, 43.1) | HILIC pos |
| Black Carbon | (2 days) | 9.0 (0.7, 18.0) | ||||||
| 202.1093 | 37.2 | N6-(delta2-isopentenyl)-adenine | M-H | PM2.5 | (1 day) | 9.5 (0.4, 19.5) | −18.8 (−32.7, −2.0) | C18 neg |
| Black Carbon | (1 day) | 10.2 (1.2, 20.0) | ||||||