Table 2.

The influence of F15599, F13714, and ketamine on locomotor activity in mice under the unpredictable chronic mild stress procedure

Treatment	UCMS	Dose (mg/kg)	Number of crossings ± SEM
Vehicle	No	-	452.0 ± 50.5
Vehicle	Yes	-	461.3 ± 58.8
F15599	Yes	8	483.5 ± 52.1
F13714	Yes	2	411.3 ± 46.8
Ketamine	Yes	1	538.8 ± 43.8

After 4 weeks of unpredictable chronic mild stress procedure, the locomotor activity was recorded individually for each animal in activity cages. After habituation time (30 min), the number of crossings of photobeams was measured during next 4 min. The tested compounds or water (vehicle) were administered per os 60 min before the test. Ketamine was administered intraperitoneally 30 min before the test. Statistical analysis: one-way ANOVA (Newman-Keuls post hoc); n=8-10 mice per group