Table 1.
Effects of single-dose nalmefene on cue-reactivity and craving in alcohol use disorder
| Investigation completed (n = 18) | Cue-reactivity task completed (n = 15) | |||||
|---|---|---|---|---|---|---|
| M | SD | n (%) | M | SD | n (%) | |
| Age | 50.3 | 13.9 | 52.3 | 14.1 | ||
| Sex | ||||||
| Male | 12 (67%) | 10 (67%) | ||||
| Female | 6 (33%) | 5 (33%) | ||||
| Smoker | 10 (56%) | 7 (47%) | ||||
| Drinks per daya | 6.4 | 4.3 | 6.8 | 4.6 | ||
| Amount of pure alcohol per day (grams)b | 76.9 | 51.8 | 81.1 | 55.3 | ||
| Abstinent daysc | 21.2 | 22.9 | 20.4 | 22.2 | ||
| Heavy drinking days (> 48 g, female/> 60 g, male)c | 54.0 | 31.6 | 53.8 | 31.1 | ||
| Number of fulfilled DSM-5 criteria for AUD | 6.4 | 1.4 | 6.4 | 1.4 | ||
| ADS | 8.7 | 4.4 | 8.5 | 4.7 | ||
| AUDIT | 17.2 | 5.8 | 17.4 | 6.1 | ||
| BDI | 6.2 | 6.1 | 6.1 | 6.2 | ||
| FTNDd | 3.4 | 3.0 | 3.3 | 2.7 | ||
Notes. M mean, SD standard deviation, ADS Alcohol Dependence Scale, AUDIT Alcohol Use Disorders Identification Test, BDI Beck Depressions Inventory, FTND Fagerström Test for Nicotine Dependence
a12 g per drink
bConversion formula: amount in ml * (Vol.-%/100) *0.8 = gram pure alcohol
cRefers to the 90 days before baseline
dRefers to the subgroup of smokers (n = 10 resp. 7)