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. 2021 Jul 20;11:14781. doi: 10.1038/s41598-021-94255-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The evolution of NMSS and each domain in 6 years. Test 1 is the baseline data and Test 2 is the follow-up data. Wilcoxon signed rank test was used. P value < 0.017 indicated significance and was marked *. The upper figure showed the trend of NMSS and lower three figures showed the trend of each domain in all patients, women and men.