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. 2021 Jul 20;5:69. doi: 10.1038/s41698-021-00206-y

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Co-occurrence of genes in all NTRK fusion-positive cancers (a). The prevalence of gene mutations was compared for NTRK fusion-positive and fusion-negative disease. Co-occurrence refers to genes that occurred in NTRK fusion-positive disease with an odds ratio greater than 1 compared with NTRK fusion-negative disease and the false discovery rate (FDR)-adjusted P-value was <0.05. Lack of co-occurrence refers to genes that did not occur in NTRK fusion-positive disease with an odds ratio less than 1 compared with NTRK fusion-negative disease and the FDR-adjusted P-value was <0.05. List of known disease-specific driver genes for different tumour types (b). The frequency of mutations found within driver genes listed in b in NTRK fusion-positive and NTRK fusion-negative colorectal cancer (CRC), breast cancer and non-small cell lung cancer (NSCLC; c). Summary of co-occurrence and mutual exclusivity of driver gene mutations and microsatellite instability-high (MSI-H) status with specific NTRK fusion-positive cancers (d). NTRK neurotrophic tyrosine receptor kinase.