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. 2021 Apr 14;125(2):220–228. doi: 10.1038/s41416-021-01366-1

Fig. 1. GNG4 is identified as a promising oncogene to develop liver metastasis of gastric cancer.

Fig. 1

The present study’s design is illustrated. In total, 57,749 genes were identified from the RNA-seq analysis of 12 specimens from gastric cancer patients with metastasis confined to the liver. The log-ratio and mean average (MA) plot of the expression levels of C and N was used to select eleven promising genes (a). DEGs indicate differentially expressed genes (upregulated). Immunohistochemistry of gastric cancer samples with liver metastasis of the adjacent gastric mucosa, primary tumour and liver metastatic lesion (b). The black bold square indicates the high-magnification area (×400). Kaplan–Meier plot of overall survival using the GSE62254 dataset stratified by the median value of GNG4 (c).